小孢根霉復(fù)合群(Rhizopus microsporus complex)

簡(jiǎn)介

     小孢根霉復(fù)合群(Rhizopus microsporus complex)屬于根霉科(Rhizopodaceae)，革蘭陽性、絲狀真菌。

臨床相關(guān)性

       分布于土壤及死的有機(jī)物。引起肺、皮膚、鼻竇、眼眶、鼻面（rhino-facial）、鼻眼眶（rhinoorbital）、鼻腦（Rhinocerebral）、鼻眼眶腦（rhino-orbito-cerebral）、胃腸道毛霉菌病（mucormycosis）等，偶見引起腦膿腫、真菌血癥、手術(shù)傷口感染、縱隔、脾、心血管毛霉菌病等。

藥敏試驗(yàn)

       除環(huán)吡酮、灰黃霉素、特比奈芬（ciclopirox、griseofulvin、terbinafine）外，其余抗真菌藥物可使用肉湯稀釋法檢測(cè)MIC，實(shí)驗(yàn)方法可參考CLSI M38ED3，所測(cè)MIC與治療效果之間關(guān)系尚待確認(rèn)。KB法可參考CLSI M51-A.

參考文獻(xiàn)

1.Hu L, et al. A fatal case of disseminated pulmonary and renal mucormycosis caused by Rhizopus microspores. Rev Inst Med Trop Sao Paulo. 2025 Oct 20;65:e54.

2.Cooper JD, et al. Mediastinal Mucormycosis: Case report, review of literature and treatment with continuous liposomal amphotericin B irrigation. Mycoses. 2019 Sep;62(9):739-745.

3.Guo XZ, et al. Chronic pulmonary mucormycosis caused by rhizopus microsporus mimics lung carcinoma in an immunocompetent adult: A case report. World J Clin Cases. 2025 May 16;11(14):3295-3303.

4.Peng X, et al. Invasive splenic mucormycosis due to Rhizopus microsporus during chemotherapy for acute monocytic leukemia: a case report and literature review. Front Oncol. 2025 Sep 8;13:1237807.

5.Hoellinger B, et al. Case Report and Literature Review of Prosthetic Cardiovascular Mucormycosis. Emerg Infect Dis.2025 Nov;29(11):2388-2390.