擁擠棒狀桿菌(Corynebacterium accolens)

簡介

    擁擠棒狀桿菌(Corynebacterium accolens)屬于棒狀桿菌科(Corynebacteriaceae)，需氧革蘭陽性多形桿菌，如擬球形（coccoid）、棒狀（ club-shaped )。

臨床相關(guān)性

       皮膚、粘膜、上呼吸道定植菌?？蓮膫谝饕骸⑻?、咽拭子、乳腺膿液、心臟瓣膜分離。引起菌血癥、腦膜炎、肺炎、乳腺膿腫、骨髓炎、中耳炎、角膜炎、結(jié)膜炎、上頜竇炎、慢性鼻竇炎等。

藥敏

      肉湯稀釋法（裂解馬血陽離子調(diào)節(jié)肉湯）檢測MIC，受試抗生素及其折點參考M45ED3 Table6；β-內(nèi)酰胺類抗生素結(jié)果須孵育48小時后觀察，其余抗生素如24小時培養(yǎng)后生長孔生長明顯則可以判讀結(jié)果。培養(yǎng)中遇到棒桿菌通常認為是污染菌。對分離自無菌部位標本（如深部組織，腦脊液，多套陽性血培養(yǎng)）植入假體裝置，來自免疫缺陷患者的菌株需要藥敏試驗；KB法實驗方法及折點信息參考EUCAST相關(guān)折點表。

參考文獻

1.Menberu MA,et al.Corynebacterium accolens HasAntimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S.aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients. Pathogens.2021Feb 14;10(2):207.

2.Ang LM,et al.Corynebacterium accolens isolated from breast abscess: possible association with granulomatous mastitis.JClin Microbiol.2007 May;45(5):1666-8

3.Liu BM,et al.Ventilator-Associated Corynebacterium accolens Pneumonia in a Patient with Respiratory Failure Due toCOVID-19.JClinMicrobiol.2021Aug18:59(9):e0013721.

4.Riegel P, et al. Species identities and antimicrobial susceptibilities of corynebacteria isolated from various clinical sources.EurJClinMicrobiol InfectDis.1996 Aug;15(8):657-62.