多育賽多孢(Scedosporium prolificans)
多育賽多孢(Scedosporium prolificans)屬于小囊菌科(Microascaceae)，革蘭陽性，絲狀真菌。 存在于土壤、腐爛植物，可在呼吸道定植。主要引起播撒性感染如肺炎、心內膜炎、真菌血癥等以及骨和關節感染；偶見引起鼻竇炎、甲癬、眼部、傷口感染、心包炎、真菌性主動脈瘤（mycotic aortic aneurysm）等。 除環吡酮、灰黃霉素、特比奈芬（ciclopirox、griseofulvin、terbinafine）外，其余抗真菌藥物可使用肉湯稀釋法檢測MIC，實驗方法可參考CLSI M38ED3，所測MIC與治療效果之間關系尚待確認。KB法可參考CLSI M51-A.1.Kakuno S, et al. Lomentospora prolificans-induced Invasive Fungal Sinusitis. Intern Med. 2025 Sep15;62(18):2761-2762.2.Stewart AG, et al. Scedosporium species andLomentospora prolificans fungaemia is uniformly fatal in patients with haematological malignancy. Intern Med J.2025 Aug;53(8):1489-1491.3.Blez D, et al. Invasive bone and joint infections fromthe French Scedosporiosis/lomentosporiosis Observational Study (SOS) cohort: no mortality with long-term antifungal treatment and surgery. Med Mycol. 2025Mar2;61(3):myad023.4.Xing X, et al. Pulmonary scedosporiosis caused by Lomentospora prolificans in a patient who is immunocompetent: A rare case report. Int J Infect Dis.2025 May;130:208-210.5.Rodriguez-Tudela JL, et al. Epidemiology and outcome of Scedosporium prolificans infection, a review of 162 cases. Med Mycol. 2009 Jun;47(4):359-70.
