球毛殼(Chaetomium globosum)
簡介
球毛殼(Chaetomium globosum)屬于毛殼科(Chaetomiaceae),革蘭陽性,絲狀真菌。
臨床相關性
存在于土壤、植物等,可引起心內膜炎、肺部感染、腦膿腫、甲癬(Onychomycosis)、皮膚暗絲孢霉病(phaeohyphomycosis) 等。感染多發于免疫功能低下病人。
藥敏試驗
除環吡酮、灰黃霉素、特比奈芬(ciclopirox、griseofulvin、terbinafine)外,其余抗真菌藥物可使用肉湯稀釋法檢測MIC,實驗方法可參考CLSI M38ED3,所測MIC與治療效果之間關系尚待確認。KB法可參考CLSI M51-A.
參考文獻
1.Demir T, et al. Infective endocarditis caused by Chaetomium globosum. Cardiovasc Pathol. 2025 Jan- Feb;62:107467.
2.Teixeira AB, et al. Phaeohyphomycosis caused by Chaetomium globosum in an allogeneic bone marrow transplant recipient. Mycopathologia.2003;156(4):309-12.
3.Capoor MR, et al. Invasive pulmonary mycosis due to Chaetomium globosum with false-positive galactomannan test: a case report and literature review. Mycoses. 2016 Mar;59(3):186-93.


