反硝化金菌(Kingella denitrificans)

簡介

      反硝化金菌(Kingella denitrificans)屬于奈瑟球菌科(Neisseriaceae)，革蘭陰性、球菌、球桿菌，苛養(yǎng)菌、非常緩慢。

臨床相關(guān)性

       口腔和上呼吸道菌群，可引起咽后膿腫（Retropharyngeal abscess )、心內(nèi)膜炎、菌血癥、膿胸、角膜潰瘍、腹透病人腹膜炎、肉芽腫等、陰道炎等。

藥敏

       肉湯稀釋法（裂解馬血陽離子調(diào)節(jié)肉湯）、HTM培養(yǎng)基或含維生素K布式肉湯培養(yǎng)基檢測MIC，受試抗生素及其折點參考M45ED3 Table9；對來自無菌部位標本（如血液、深部組織）的分離株，特別是植入假體裝置和免疫缺陷患者的菌株，或者患者對β-內(nèi)酰胺類抗生素治療方案過敏時，需要進行藥敏試驗；頭孢曲松、頭孢噻肟、阿奇霉素罕見“非敏感”表型、如遇須復(fù)查后送上級實驗室確認。

參考文獻

1.Kopyt N,et al.A case of suppurative peritonitis by a commensal oral organism,Kingella denitrificans,in an adult peritoneal dialysis patient.Perit Dial Int.2015Jan- Feb;35(1):105-7.

2.Molina R,et al.Empyema caused by Kingella

denitrificans and Peptostreptococcus spp. in a patient with bronchogenic carcinoma.Eur Respir J.1988 Oct;1(9):870-1.

3.Rajanna DM,et al.Retropharyngeal abscess from an unusual organism-Kingella denitrificans-in a patient on low-dose methotrexate.Ear Nose Throat J.2011 Jul;90(7):E15-7.

4.Kim YH,et al.Isolation of Kingella denitrificans from a corneal ulcer.Cornea.2011 Apr;30(4):472-3.

5.Minamoto GY,et al.Kingella denitrificans as a cause of granulomatous disease in a patient with AlDS.Clin Infect Dis.1992 Dec;15(6):1052-3.

6.Salvo S,et al.[Vaginitis caused by Kingella denitrificans in a 3-year-old female patient].Enferm Infecc Microbiol Clin.1993 Aug-Sep;11(7):395-6.

7.Brown AM,et al. Septicaemia with probable endocarditis caused by Kingella denitrificans.JInfect.1987 Nov;15(3):225-8.